Finally, while Δ<sup>9</sup>-THC did not affect the levels of CD4<sup>+</sup> T cells, it significantly reduced absolute CD8<sup>+</sup> T cell numbers in peripheral blood at 14 and 150 days post-SIV infection.
Finally, the ability of Δ(9)-THC to block the miR-150-IRAK1 regulatory cascade highlights the potential of cannabinoids to inhibit persistent inflammation/immune activation in HIV/SIV infection.